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apceth Inc apceth-201 mscs
Mesenchymal stem cells in graft-versus-host disease
Apceth 201 Mscs, supplied by apceth Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/apceth-201+mscs/apceth+201/pmc09446388-53-14-14
Average 90 stars, based on 1 article reviews
apceth-201 mscs - by Bioz Stars, 2026-09
90/100 stars

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1) Product Images from "Insights into mechanisms of graft-versus-host disease through humanised mouse models"

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models

Journal: Bioscience Reports

doi: 10.1042/BSR20211986

Mesenchymal stem cells in graft-versus-host disease
Figure Legend Snippet: Mesenchymal stem cells in graft-versus-host disease

Techniques Used: Derivative Assay

Related Articles

Derivative Assay:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Produced:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

In Vitro:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Inhibition:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Purification:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Clinical Proteomics:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Activity Assay:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Functional Assay:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

In Vivo:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Concentration Assay:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Protease Inhibitor:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Expressing:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Marker:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Control:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Isolation:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Mouse Assay:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Injection:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Generated:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Transduction:

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Nonetheless, we detected a significant increase in the percentage of Tregs that express PD-1, recovered from the bone marrow of mice treated with apceth-201 MSCs, which is consistent with previous results described for in vitro co-cultures of MSCs with Tregs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: We generated MSCs expressing the anti-inflammatory serine protease inhibitor AAT, via lentiviral transduction, resulting in the apceth-201 MSCs reported on here.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Biodistribution of apceth-201 MSCs Recruit Immune Cells In Vitro The low persistence we observed for apceth-201 is in agreement with reports by others for native MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: 31 , 32 Although the amount of AAT produced by apceth-201 seems to be small when compared to the very high doses of pure AAT administered, our results suggest that apceth-201 has the advantage of targeted delivery.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Extrapolating these results, we predict that GvL responses may also proceed unfettered in patients whose GvHD is treated with apceth-201 MSCs.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: These findings demonstrate that apceth-201 MSCs are vastly superior to currently available anti-inflammatory drugs, with regard to maintaining protective immunity. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Administering apceth-201 Does Not Impair Normal Immune Responses (A) Mice were either vaccinated with Keyhole Limpet Hemocyanin (KLH) or sham injected.

Article Title: Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD
Article Snippet: Collectively, results from the GvHD models, together with those of the KLH vaccination study, suggest that apceth-201 MSCs modulate and reduce the unwanted inflammatory reactions that mediate GvHD but do not suppress physiological T cell-dependent antibody response following vaccination.

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models
Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .



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Mesenchymal stem cells in graft-versus-host disease

Journal: Bioscience Reports

Article Title: Insights into mechanisms of graft-versus-host disease through humanised mouse models

doi: 10.1042/BSR20211986

Figure Lengend Snippet: Mesenchymal stem cells in graft-versus-host disease

Article Snippet: NSG (2 Gy) , 1 × 10 7 (i.v.) , 2 × 10 6 Apceth-201 MSCs (i.v.) days 14 and 18 , ↑ Survival , ↓ IFN-γ ↓ TNF-α ↓ IL-5 , [ ] .

Techniques: Derivative Assay